John E. Karlin, 1918-2013: John E. Karlin, Who Led the Way to All-Digit Dialing, Dies at 94


Courtesy of Alcatel-Lucent USA


John E. Karlin, a researcher at Bell Labs, studied ways to make the telephone easier to use.







A generation ago, when the poetry of PEnnsylvania and BUtterfield was about to give way to telephone numbers in unpoetic strings, a critical question arose: Would people be able to remember all seven digits long enough to dial them?




And when, not long afterward, the dial gave way to push buttons, new questions arose: round buttons, or square? How big should they be? Most crucially, how should they be arrayed? In a circle? A rectangle? An arc?


For decades after World War II, these questions were studied by a group of social scientists and engineers in New Jersey led by one man, a Bell Labs industrial psychologist named John E. Karlin.


By all accounts a modest man despite his variegated accomplishments (he had a doctorate in mathematical psychology, was trained in electrical engineering and had been a professional violinist), Mr. Karlin, who died on Jan. 28, at 94, was virtually unknown to the general public.


But his research, along with that of his subordinates, quietly yet emphatically defined the experience of using the telephone in the mid-20th century and afterward, from ushering in all-digit dialing to casting the shape of the keypad on touch-tone phones. And that keypad, in turn, would inform the design of a spate of other everyday objects.


It is not so much that Mr. Karlin trained midcentury Americans how to use the telephone. It is, rather, that by studying the psychological capabilities and limitations of ordinary people, he trained the telephone, then a rapidly proliferating but still fairly novel technology, to assume optimal form for use by midcentury Americans.


“He was the one who introduced the notion that behavioral sciences could answer some questions about telephone design,” Ed Israelski, an engineer who worked under Mr. Karlin at Bell Labs in the 1970s, said in a telephone interview on Wednesday.


In 2013, the 50th anniversary of the introduction of the touch-tone phone, the answers to those questions remain palpable at the press of a button. The rectangular design of the keypad, the shape of its buttons and the position of the numbers — with “1-2-3” on the top row instead of the bottom, as on a calculator — all sprang from empirical research conducted or overseen by Mr. Karlin.


The legacy of that research now extends far beyond the telephone: the keypad design Mr. Karlin shepherded into being has become the international standard on objects as diverse as A.T.M.’s, gas pumps, door locks, vending machines and medical equipment.


Mr. Karlin, associated from 1945 until his retirement in 1977 with Bell Labs, headquartered in Murray Hill, N.J., was widely considered the father of human-factors engineering in American industry.


A branch of industrial psychology that combines experimentation, engineering and product design, human-factors engineering is concerned with easing the awkward, often ill-considered marriage between man and machine. In seeking to design and improve technology based on what its users are mentally capable of, the discipline is the cognitive counterpart of ergonomics.


“Human-factors studies are different from market research and other kinds of studies in that we observe people’s behavior and record it, systematically and without bias,” Mr. Israelski said. “The hallmark of human-factors studies is they involve the actual observation of people doing things.”


Among the issues Mr. Karlin examined as the head of Bell Labs’ Human Factors Engineering department — the first department of its kind at an American company — were the optimal length for a phone cord (a study that involved gentle, successful sabotage) and the means by which rotary calls could be made efficiently after the numbers were moved from inside the finger holes, where they had nestled companionably for years, to the rim outside the dial.


John Elias Karlin was born in Johannesburg on Feb. 28, 1918, and reared nearby in Germiston, where his parents owned a grocery store and tearoom.


He earned a bachelor’s degree in philosophy, psychology and music, and a master’s degree in psychology, both from the University of Cape Town. Throughout his studies he was a violinist in the Cape Town Symphony Orchestra and the Cape Town String Quartet.


Moving to the United States, Mr. Karlin earned a Ph.D. from the University of Chicago in 1942. Afterward, he became a research associate at Harvard; he also studied electrical engineering there and at the Massachusetts Institute of Technology.


At Harvard, Mr. Karlin did research for the United States military on problems in psychoacoustics that were vital to the war effort — studying the ways, for instance, in which a bomber’s engine noise might distract its crew from their duties.


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FBI searches Las Vegas home of fugitive









Federal and local authorities served a search warrant at the Las Vegas home of an ex-police officer sought in connection with a series of shootings in Southern California, but said the suspect was not located.


FBI spokeswoman Laura Eimiller confirmed agents and Las Vegas police searched the home Thursday as part of the ongoing investigation into Christopher Jordan Dorner, 33, but did not elaborate as to what was recovered. The surrounding neighborhood was cleared as a precaution, she said.


No one was home at the time, Eimiller said.








PHOTOS: Manhunt for ex-LAPD officer


Several law enforcement agencies are involved in the ongoing manhunt for Dorner and alerts have been issued all across California and in Nevada, warning Dorner was considered "armed and extremely dangerous." Dorner was believed to be carrying multiple weapons, including an assault rifle.


In California, a SWAT team clad in military fatigues spent Thursday afternoon combing the mountain community of Big Bear after Dorner's burned-out truck was found on a forest road. Authorities were going door-to-door and checking all vehicles coming and going from the mountain.


Dorner, who was fired from the LAPD in 2009, is suspected of shooting three police officers, one of whom died, in Riverside County early Thursday.


PHOTOS: Manhunt for ex-LAPD officer


He also is suspected of killing a couple who were found shot in a car in Orange County earlier this week. One of the victims was the daughter of a former LAPD captain named in a lengthy online manifesto that law enforcement officials attributed to Dorner.


The Los Angeles Police Department had dispatched units across the region to protect at least 40 officers and others named in the document, which threatened "unconventional and asymmetrial warfare" against police.

Dorner received awards for his expertise with a rifle and pistol, according to military records obtained by The Times. He received an Iraq Campaign Medal and was a member of a mobile inshore undersea warfare unit.


Riverside Police Chief Sergio Diaz, calling the attack on his officers a "cowardly ambush," said Dorner is suspected of opening fire with a rifle about 1:30 a.m. Thursday as he pulled up to two police officers waiting at a traffic light.

The attack was carried out about 20 minutes after Dorner wounded an LAPD officer in a shooting in nearby Corona, police said.


Early Thursday, two women delivering the Los Angeles Times in Torrance were shot by Los Angeles police who were headed to the home of a police captain named in the manifesto.

The women, shot in the 19500 block of Redbeam Avenue, were taken to area hospitals, Torrance Police Lt. Devin Chase said. One suffered a minor wound, and the other was struck twice and listed in stable condition, LAPD Chief Charlie Beck told reporters.


"Tragically," Beck said, "we believe this is a case of mistaken identity."





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Apparent Facebook Widget Snafu Brings Down Sites











Several sites across the web could not be reached by some visitors on Thursday afternoon, apparently because of a problem with Facebook widgets embedded in the sites. Several sites — including Business Insider, Huffington Post and Salon — were reportedly affected, redirecting visitors to a Facebook error page.


Facebook did not immediately respond to a request for comment, but the problem has apparently been fixed. The problem was first reported by Marketing Land.


When trying to visit a page that used Facebook Connect or Like widgets, users were redirected to a page saying simply “An error occurred. Please try again later.” When they clicked the “Okay” button, they were taken to an error page. If they hit back, they would get to the page they were trying to visit momentarily before being automatically forwarded to the error page again.


Facebook provides code to embed widgets that display information such as which of your friends like a site’s Facebook page, or which articles have recently been “liked” by a friend. These widgets execute JavaScript code in the user’s web browser that originates at Facebook, not the site that the user is trying to view. The problem only seems to affect users who are not logged into Facebook.


Home Page Photo: Pshab / Flickr


Update: Facebook has now said: “For a short period of time, there was a bug that redirected people logging in with Facebook from third party sites to Facebook.com. The issue was quickly resolved, and Login with Facebook is now working as usual.”






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California boy to be arraigned in “swatting” prank on actor Kutcher






LOS ANGELES (Reuters) – Prosecutors charged a 12-year-old boy on Thursday with making a false emergency call that sent police swarming to the home of actor Ashton Kutcher in a “swatting” prank.


The name of the boy, who was arrested by Los Angeles police in December, was withheld due to his age. He was scheduled to be arraigned in a juvenile court in Los Angeles on Friday.






The trend toward placing false emergency calls is known as “swatting” because SWAT (Special Weapons and Tactics) officers often are sent to the purported crime scenes. Authorities say such situations can be dangerous due to the risk of a misunderstanding between police and occupants of a building.


The boy has been charged with two felony counts each of making false bomb threats and computer intrusion in connection with the October 3 emergency call that drew police to the Hollywood Hills home of Kutcher, star of the sitcom “Two and a Half Men,” and a similar call on October 10 that sent police to a Wells Fargo Bank.


Authorities have accused the boy of having reported men armed with guns and explosives in Kutcher’s home and that several people had been shot. Dozens of emergency personnel were sent to the house. Kutcher was not home at the time.


Swatting calls in recent months have also sent police to the homes of singers Justin Bieber and Miley Cyrus.


(Reporting by Alex Dobuzinskis; Editing by Bill Trott)


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Peter Hauri, Psychologist Who Focused on Insomnia, Dies at 79





Peter Hauri, a psychologist who was among the first researchers to study the mysterious mechanics of a good night’s sleep, and who established widely used guidelines for avoiding insomnia without drugs, died on Jan. 31 in Rochester, Minn., where he had been director of the Mayo Sleep Disorders Center until he retired in 2000. He was 79.




The cause was complications of a brain injury sustained the day before in a fall, a family spokesman said.


Dr. Hauri’s early work included studies of narcolepsy and sleepwalking. He later studied the use of biofeedback in helping people with insomnia to fall asleep, and he measured the relative depths of so-called rapid eye movement, or REM, sleep and non-REM sleep. Those studies established him as part of the first generation of scientists to recognize sleep as an organized physiological process, not a simple “turning off” of the brain.


He was best known, though, for a 1992 book, “No More Sleepless Nights.” Written with Shirley Linde, it outlined some of the practical strategies he had developed for helping people sleep without taking pills.


The book mainly describes a painstaking process of self-observation and note-taking, followed by behavior modification.


Dr. Hauri said the most important thing he had learned in his research — in sleep lab experiments with volunteers draped in bridal trains of wires and electrodes so he could record the pulsing of their sleeping, or nonsleeping, brains — was that, like snowflakes, every person’s sleeping problem was unique. “There is no one set of rules that can be mimeographed and given to every patient who comes into the office,” he said in a 2010 videotaped interview for the archive of the Sleep Research Society.


Nonetheless, Dr. Hauri devised guidelines that became the standard medical advice of recent decades. Among them was this paradox of insomnia therapy strategies: Never try to sleep. “The more a person tries to sleep, the more aroused he or she gets,” Dr. Hauri said in an interview. Instead, he advised, get out of bed — and leave the bedroom — until sleepiness calls.


Another suggestion: Eliminate the bedroom clock, or turn it to the wall, out of reach. “There is no scientific proof,” Dr. Hauri said in 2010, “but I’m convinced of that one: Getting rid of the alarm clock works.”


Peter Johannes Hauri was born on June 25, 1933, in Sirnach, Switzerland, one of six children of Rudolf and Verena Hauri. After graduating from a teachers college, he taught junior high school students in Switzerland for several years until an opportunity arose to study in the United States. In 1960 he received a bachelor’s degree in psychology from North Central College in Naperville, Ill. He studied psychology from 1960 to 1965 at the University of Chicago, where he received his Ph.D.


Survivors include his wife, Cindy, and their son, Matthew. He is also survived by a daughter, Heidi Hauri-Gill; a son, David Courard-Hauri; and four grandchildren from a previous marriage.


In the 2010 archive interview, Dr. Hauri was asked what had begun his interest in sleep.


He replied with an impish smile, “My mother was a very famous insomniac.” And, he added, “I don’t sleep so well myself.”


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Chinese Imports and Exports Soar in January


HONG KONG — January trade data from China on Friday showed a surge in exports and imports from a year earlier — a phenomenon that was largely due to the timing of the Lunar New Year holiday, but that also supported the view that the Chinese economy is firming.


Economic data from China are often severely distorted by the holiday, the highlight of the Chinese calendar, when many factories shut down for a week or more.


The holiday this year takes place in February — the first day of the Lunar New Year is on Sunday — but last year it fell squarely in January, cutting down on the number of working days during that month.


The trade data released Friday reflected this with a large increase compared with the year before, as analysts had expected. Exports climbed 25 percent from January 2012, according to the General Administration of Customs, and imports soared 28.8 percent.


Both figures beating expectations by a wide margin, however, supported the view that the rise was also caused in part by healthier domestic and overseas demand.


“This strong export number cannot be fully explained by the Chinese New Year effect alone,” Zhiwei Zhang, chief China economist at Nomura in Hong Kong, said in a research note.


“These data suggest that external and domestic demand are both strong, which supports our view that the economy is on track for a cyclical recovery” in the first half of this year, he added.


Dariusz Kowalcyk, an economist at Crédit Agricole in Hong Kong, said “we need to wait for February results to have the full picture of trade at the start of 2013.”


However, he added, “one trend is clear: exports have been doing very well recently. This may be a sign of improved external demand, but is also a testimony to the resilience of Chinese exporters and to their competitiveness.”


The Chinese economy has been accelerating gradually in the past few months, reversing a marked slowdown that had raised fears of a possible “hard landing” in China early last year.


Improved overseas demand, combined with a string of government-mandated stimulus measures, have gradually propped up growth and dispelled those fears.


Data released last month showed the Chinese economy expanded just 7.8 percent last year — down from 9.3 percent in 2011 and 10.4 percent in 2010 — but many analysts expect slightly faster growth again in 2013.


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L.A. County Sheriff's Department intends to fire seven deputies









Seven Los Angeles County sheriff's deputies have been notified that the department intends to fire them for belonging to a secret law enforcement clique that allegedly celebrated shootings and branded its members with matching tattoos, officials said.


The Times reported last year about the existence of the clique, dubbed the Jump Out Boys, and the discovery of a pamphlet that described the group's creed, which required aggressive policing and awarded tattoo modifications for police shootings.


The seven worked on an elite gang-enforcement team that patrols neighborhoods where violence is high. The team makes a priority of taking guns off the street, officials said.





The Sheriff's Department has a long history of secret cliques with members of the groups having reached high-ranking positions within the agency. Sheriff officials have sought to crack down on the groups, fearing that they tarnished the department's reputation and encouraged unethical conduct.


In the case of the Jump Out Boys, sheriff's investigators did not uncover any criminal behavior. But, sources said, the group clashed with department policies and image.


Their tattoos, for instance, depicted an oversize skull with a wide, toothy grimace and glowing red eyes. A bandanna with the unit's acronym is wrapped around the skull. A bony hand clasps a revolver. Smoke would be tattooed over the gun's barrel for members who were involved in at least one shooting, officials said.


One member, who spoke to The Times and requested anonymity, said the group promoted only hard work and bravery. He dismissed concerns about the group's tattoo, noting that deputies throughout the department get matching tattoos. He said there was nothing sinister about their creed or conduct. The deputy, who was notified of the department's intent to terminate him, read The Times several passages from the pamphlet, which he said supported proactive policing.


"We are alpha dogs who think and act like the wolf, but never become the wolf," one passage stated, comparing criminals to wolves. Another passage stated, "We are not afraid to get our hands dirty without any disgrace, dishonor or hesitation... sometimes (members) need to do the things they don't want to in order to get where they want to be."


Department spokesman Steve Whitmore said starting the termination process shows that Sheriff Lee Baca "does not take any of this lightly and will move forward with the appropriate action."


Investigators were less concerned about the tattoos, and more focused on the suspected admiration they showed for officer-involved shootings, which are expected to be events of last resort. The deputy told The Times, however, that investigators reviewed their shootings and arrests and found nothing unlawful.


"We get called a gang within the badge? It's unfair," he said. "People want to say you have a tattoo. So do fraternities. Go to Yale. Are they a gang?.... Boy Scouts have patches and they have mission statements, and so do we."


"We do not glorify shootings," he continued. "What we do is commend and honor the shootings. I have to remember them because it can happen any time, any day. I don't want to forget them because I'm glad I'm alive."


If the firings are upheld, it would be one of the largest terminations over one incident in the department's history. In 2011, the department fired about half a dozen deputies who were also said to have formed a clique. Those deputies worked on the third floor of Men's Central Jail and allegedly threw gang-like three-finger hand signs. They were fired after they fought two fellow deputies at an employee Christmas party and allegedly punched a female deputy in the face.


As part of the widening federal investigation of the Sheriff's Department, a criminal grand jury recently subpoenaed the agency for materials relating to deputy cliques, specifically citing several of the groups including the "3000 boys" and the Jump Out Boys.


When the pamphlet revealing the existence of the Jump Out Boys was initially found, officials didn't know if the group was real. But eventually, one member came forward and named the others, according to an official who asked for anonymity because he was not authorized to speak to the media.


The seven deputies can fight the department's decision to fire them.


robert.faturechi@latimes.com





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Microsoft Teases Future Surface Pro Accessories With Extra Battery Power



Days before Surface Pro’s release date, Microsoft is already teasing the types of accessories we’ll see for the device.


In a Reddit AMA hosted on Wednesday, members of the Surface Team responded to user questions, and suggested that a Surface Pro cover that would double as an extra battery pack is in the works. Good thing, too, since we found that the Surface Pro could barely get around four hours of normal usage.


Naturally, that’s a major concern for people considering buying the computer — Reddit members brought it up on multiple occasions. Asked about the new connectors at the bottom of the Surface Pro on either side of the cover port, a Microsoft rep said, “At launch we talked about the ‘accessory spine’ and hinted at future peripherals that can click in and do more. Those connectors look like can carry more current than the pogo pins, don’t they?”


The cryptic answer was fleshed out in another response. A redditor specifically asked if Microsoft plans to make a thicker keyboard with an extra battery pack.


“That would require extending the design of the accessory spine to include some way to transfer higher current between the peripheral and the main battery. Which we did,” a Surface Team member replied.


Considering that Microsoft already has released two covers for Surface Pro and Surface RT, along with a Surface-branded Wedge Touch Mouse, it’s not hard to imagine the company expanding its Surface accessory lineup. It’s a natural next step as the company continues to focus on its hardware division, which has traditionally offered accessories like mice and keyboards.


The Reddit AMA also covered issues like Surface Pro’s lack of storage space and whether the company plans to release a 3G or 4G Surface. The latter answer was a roundabout “no.” As for storage space, the Surface Team’s Marc DesCamp said, once again, that you can extend storage through the USB 3.0 port and microSDX card slot. He also mentioned that initial reports of available storage space (23GB for the 64GB model, and 83GB for the 128GB model) are conservative; you actually get around 6 to 7GB more than that.


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How Ang Lee Took a Tiger by the Tail to Create ‘Life of Pi’






LOS ANGELES (TheWrap.com) – It would have been foolish to predict what “Life of Pi” – has become: a box-office phenomenon that has swept one country after another, a game changer in its use of 3D and computer graphics and a critical darling with 11 Oscar nominations including best picture, director, screenplay, cinematography and two for composer Mychael Danna.


“It still comes as a surprise,” director Ang Lee told TheWrap. “But a wonderful surprise. For a long time I felt that it’s a privilege to even make this movie. So we’re very happy.”






Everything about “Life of Pi,” based on the bestselling novel by Yann Martel, represented an uncommon risk. A pensive drama without a single movie star or, for that matter, a face vaguely familiar to American audiences, the project cost $ 130 million, highly unusual in today’s Hollywood. (Even “Les Misérables” cost just $ 60 million.)


Further, the movie takes place almost entirely on the ocean, in 3D and with a CG tiger, factors that required technological machinations not guaranteed to work. Beyond that, given its ponderous price tag, the movie had to appeal to a very broad audience to pay off.


And it has. An uplifting story about the survival of the human spirit and the power of imagination, “Life of Pi” has been embraced across cultures and nations around the globe, with the movie setting new benchmarks in China, sweeping Latin America and taking in $ 450 million worldwide while still in release.


“The pattern of how this movie plays is kind of strange. I’ve never experienced it before,” Lee said of “Pi’s” overwhelming international appeal. “It was made to be a big movie, with lots of commercials everywhere. But it’s a philosophical movie – an Indian boy, a digital tiger, an ambiguous ending. I didn’t know if it would work or not.”


The novel tells the story of a shipwrecked Indian boy, Pi, adrift on a lifeboat with a Bengal tiger, and adds a twist at the end to make you question everything you’ve read. “Pi’s” journey to the screen took the better part of a decade and began conventionally enough. Producer Gil Netter sent Fox 2000 veteran producer Elizabeth Gabler the book shortly after it was published, and they optioned it for Fox in 2002.


She commissioned a script from Dean Georgaris for director M. Night Shyamalan, but Georgaris never completed it. Director Alfonso Cuaron (“Children of Men”) signed on and then left. Jean-Pierre Jeunet (“Delicatessen”) picked up the project, then he dropped out, too.


Finally she approached Lee, whom she’d admired for years. “He told me I was crazy,” Gabler said. “I told him he had to do it.”


The problem was, most people considered the story of young Pi to be unmakeable.


You couldn’t film it with real tigers. Could a computer-generated tiger be believable? For Lee, who was revered for such movies as “Brokeback Mountain” and “Sense and Sensibility,” but who had also learned a lot making the tech-heavy but unsuccessful “Hulk,” the impossibility of the challenge was part of the appeal.


“That’s a small part,” he confessed. “That’s ego. But that’s not a good enough reason. Artistically, it’s a philosophical book. The movie has an unfriendly ending. It pulls the rug out from the audience’s feet. Your attention is mandatory.”


And those difficulties, to Lee, were irresistible. “It’s challenging, but it’s a thrill. If you can do it, you can swagger around. When people say, ‘How the hell did you do that?’ there’s a certain amount of satisfaction.” The night before Lee spoke to the TheWrap, he had been at a critics’ award ceremony where he was approached by Steven Spielberg. “He said to me, ‘I tried to figure out how you do that,’ Of course, that’s nice!”


But back to the movie: Lee dove into making the story his own, conducting intensive research on tigers and computer graphics, and investigating the logistics of creating a set where the ocean would seem like a real character. He decided to do the film in 3D. The price continued to rise – and with it the anxiety of then-Fox chairmen Jim Gianopulos and Tom Rothman.


Gabler recalled: “Tom and Jim said, ‘We can’t make this movie. It’s too risky. Give it back to him.’” Lee got on a plane to Los Angeles. At a meeting with the studio chiefs, he showed an animated mock-up of the shipwreck scene, complete with swimming zebras. And he showed them a 12-minute tape of an unknown actor, Suraj Sharma, reciting the monologue from the end of the movie: Pi, in a hospital bed, recounting an alternative, grisly fate that could have befallen the survivors of a shipwreck. “When we saw it, the lights came up, and they said OK,” said Gabler.


So the studio, in Lee’s words, “sweated it out” with him over four years, gambling on the notion that the film just might be the international hit it would have to be to make back Fox’s investment.


The time included three months of rehearsal with the inexperienced Sharma and another seven months shooting. The Taiwanese government gave favorite son Lee an abandoned airport where the filmmakers built a series of soundstages, saving the production millions.


One studio was used to build a massive water tank, where the challenge was to simulate the waves of a vast ocean and not see the water that bounced off the sides of a tank. They built 12 machines to suck in water and shoot it out, creating two-story waves and endless ripples.


The time included three months of rehearsal with the inexperienced Sharma and another seven months shooting. The Taiwanese government gave favorite son Lee an abandoned airport where the filmmakers built a series of soundstages, saving the production millions.


One studio was used to build a massive water tank, where the challenge was to simulate the waves of a vast ocean and not see the water that bounced off the sides of a tank. They built 12 machines to suck in water and shoot it out, creating two-story waves and endless ripples.


As for Sharma, Lee took the 17-year-old novice under his wing, teaching him method acting and guiding him in yoga practice. The two became inseparable, and Sharma watched as Lee increasingly took on the qualities of the character Pi.


“He himself is a very intense person,” Sharma told TheWrap. “Ang moved toward Pi right through the movie. It was really intense. And in many ways I feel like he was a little like Pi; the way he thinks is similar. The aura is similar. He has that similar patience with things but a certain perseverance to it. But nice at the same time – I can’t explain it. It’s the way his back is bent … Ang is a lot like his work. It’s very simple from the outside but it has a lot of complexities on the inside. Kind of like Pi.”


For Lee, the result was one that both exhausted and exhilarated him. The story of Pi, he says, is the story of the essence of filmmaking.


“It’s a project that examines illusion. The power of storytelling. The importance of illusion – is it more real than what we can prove?” he reflected.


“I’m a storyteller. I create illusions. I believe in that more than in things I can touch. And this gets to the bottom of it all.”


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Daniel Doctoroff Enlists Bloomberg in A.L.S. Research


Nicole Bengiveno/The New York Times


Daniel L. Doctoroff, second from right, chief executive of Bloomberg L.P., at Columbia University’s Motor Neuron Center.







Daniel L. Doctoroff watched in pain as his father developed a limp one day, was found to have Lou Gehrig’s disease, and died within two years. Then an uncle also developed symptoms of the same disease, and died soon after.




Now Mr. Doctoroff, like many other relatives of Lou Gehrig’s disease victims, worries that he or his children may someday develop the illness.


But unlike many, he is in a position to try to do something about it. At a time when scientists are making rapid gains in the genetic roots of many diseases, Mr. Doctoroff, a former deputy mayor and private equity investor, is working with Mayor Michael R. Bloomberg and a private equity director, David M. Rubenstein, to put together a $25 million package of donations to support research to try to cure this rare and usually fatal degenerative neurological illness.


“This is a devastating disease,” Mr. Doctoroff said in an interview this week in the glass high-rise on the Upper East Side that houses Bloomberg L.P., the mayor’s media and financial information company, where Mr. Doctoroff is now chief executive. “Up to now, there’s been basically no hope. I have the resources, and I think it’s my obligation to do that.”


The gift is part of a wave of investment based on the booming field of genomic analysis. The money will go to a project called Target A.L.S., a consortium of at least 18 laboratories, including ones at Columbia and at Johns Hopkins, the mayor’s alma mater, working to find biological “targets,” like gene mutations, and the biochemical changes they cause in the spinal cord, that could be used to test potential drug therapies for the disease, formally known as amyotrophic lateral sclerosis.


It comes on top of a previous $15 million gift by Mr. Doctoroff, Bloomberg Philanthropies and other donors. By comparison, the National Institutes of Health, the single largest source of research financing for the disease, expects to give $44 million in 2013.


This is not Mr. Bloomberg’s first time supporting charitable causes that are dear to his close associates. The mayor quietly gave at least $1 million to put the name of his top deputy mayor, Patricia E. Harris, on a new academic center at her alma mater, Franklin & Marshall College in Lancaster, Pa.


Mr. Doctoroff said the conversation about A.L.S. in which he got Mr. Bloomberg involved “lasted about five seconds.” He declined to say what share of the money each of the three donors was giving.


Mr. Rubenstein, a founder of the Carlyle Group, said Wednesday that he had long been fascinated with A.L.S. because of its association with Gehrig, the baseball player who died of it. He wondered why more than 70 years later so little progress had been made in treating it.


He said he jumped at the chance to join in because he thought that A.L.S. research was underfinanced owing to the rarity of the disease, and that even a small amount of money could make a big difference.


In the Bloomberg administration, where he was deputy mayor for economic development and rebuilding from 2002 to 2008, Mr. Doctoroff was best known for his dogged — and ultimately dashed — attempt to bring the 2012 Olympics to New York City. (London got the Games.) Now that he has left City Hall, he no longer rides his bike to work — he says the 2.6-mile route from the Upper West Side to his office is too short — but he sometimes runs.


At Bloomberg, he sits in front of a conference room with walls of hot-pink glass, while carp swim in a giant fish tank nearby. He keeps no family photos or other personal mementos on his desk, and talking about his family’s disease history does not seem easy for him.


A.L.S. is rare, with about 2 new cases diagnosed a year per 100,000 people, according to the A.L.S. Association. A vast majority of cases are “sporadic,” in people who have no family history, while only 5 to 10 percent of cases are inherited. There appear to be no racial, ethnic or socioeconomic predispositions.


There is some speculation about environmental factors, like exposure to toxic chemicals and high physical activity that athletes might endure, “but nothing firm,” said Christopher E. Henderson, a researcher at Columbia and the Target A.L.S. project’s scientific director. Some researchers suspect a link between A.L.S. and head trauma suffered by professional football players.


Mr. Doctoroff’s father, Martin, an appeals court judge in Michigan, received the diagnosis in 2000 and died in 2002. One of Martin Doctoroff’s brothers, Michael, was found to have the disease in 2009 and died in 2010.


“When my father contracted the disease and passed away, it was very easy to chalk it up to bad luck,” Mr. Doctoroff said. “When my uncle got it, it obviously had broader implications.”


Given his family history, Mr. Doctoroff estimates that there is a 50-50 chance that he has the gene, C9orf72, that could lead to A.L.S. But he has chosen not to be tested, which would have implications not just for him but for his three children. “It’s very personal, but I’m not sure that I want to know,” he said.


Even when family members develop the disease, it can occur at vastly different ages, so he could still be in suspense even after testing. “Assuming you have the gene, you don’t know when you would actually get the disease,” he said. His uncle was 71. His father was 66. He is now 54.


Sheelagh McNeill contributed reporting.



This article has been revised to reflect the following correction:

Correction: February 6, 2013

An earlier version of a picture caption with this article misstated Daniel L. Doctoroff’s title at Bloomberg L.P. He is the chief executive, not the executive director.



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